Computer- aided biopharmaceutical characterization: gastrointestinal absorption simulation - Computer-Aided Applications in Pharmaceutical Technology - page 196

Effects of dosage forms on CBZ regional absorption:
(a) fasted; (b) fed (reprinted from Zhang et al., 2011;
with permission from Springer)

Figure 6.6

￿

￿ ￿

and PK parameters. Table 6.7 shows that some of the input parameters
selected for simulation differed from the values used by Zhang et al.
(2011). For example, drug particle radius was three times larger in the
study of Zhang et al. (2011), which inevitably led to slower in vivo
dissolution, and consequently, drug absorption. Another notable
difference referred to PK parameters employed for the simulations.
Opposite to Zhang et al. (2011), who used a two-compartment model to
describe CBZ pharmacokinetics following administration of an IR
formulation, in our study, a one-compartment model was employed, and
the corresponding PK parameters were used as inputs. Consequently, the
generated absorption models differed, and the simulated PK profi les
diverged, as illustrated by the predicted plasma PK parameters (Table 6.8).