Computer- aided biopharmaceutical characterization: gastrointestinal absorption simulation - Computer-Aided Applications in Pharmaceutical Technology - page 191

GastroPlus™ predicted and observed (Najib et al.,
2002) mean GLK plasma C p -time profi les following
administration of a single 80-mg GLK IR tablet

Figure 6.4

Table 6.5

Default and adjusted ASF values

Compartment Default ASFs Optimized ASFs

Stomach 0 0

Duodenum 2.760 1.289

Jejunum 1 2.699 1.262

Jejunum 2 2.683 1.256

Ileum 1 2.632 1.234

￿

￿ ￿

Ileum 2 2.589 1.216

Ileum 3 2.512 1.181

Caecum 0.339 1.782

Asc colon 0.549 2.417

of IR tablets varied between 2.3 and 4.5 h (Kobayashi et al., 1981;
Glowka et al., 1998; Najib et al., 2002)), the simulated value of 3.68 h
was considered a reasonable estimate.
GastroPlus™ generated regional absorption distribution demonstrated
that the majority of GLK, formulated in IR dosage form, is absorbed in
the duodenum and jejunum (69.9%), while the rest of the dose is absorbed
in the mid- and distal GI regions (Figure 6.5).