Computer- aided biopharmaceutical characterization: gastrointestinal absorption simulation - Computer-Aided Applications in Pharmaceutical Technology - page 187

Table 6.2

ASF values employed

Compartment Model 1 Model 2

(GastroPlus™ default*)

Stomach 0 0

Duodenum 1000 2.687

Jejunum 1 500 2.668

Jejunum 2 2.600 2.633

Ileum 1 0.500 2.588

Ileum 2 0.500 2.551

Ileum 3 5.547 2.460

Caecum 6.098 1.328

Asc colon 12.240 1.995

* Opt logD Model SA/V 6.1

￿

￿ ￿

GastroPlus™ Model 1 and Model 2 predicted and in
vivo observed mean NIM plasma profi les following
administration of a single 100 mg nimesulide IR tablet
(a); predicted dissolution and absorption profi les (b)

Figure 6.3