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Figure 5.18
SOMs developed for fl uid-bed granulation process.
F1 - inlet air fl ow rate; T1 - inlet air temperature;
T2 - temperature of air after heater; T3 -
temperature of air before granulator; T6 -
granulation chamber temperature; T8 - outlet
air temperature; U1 - inlet air relative humidity,
outlet air relative humidity; R1 - refl ectance at
1813 nm; R2 - refl ectance at 1998 nm; R3 -
refl ectance at 2136 nm; R4 - refl ectance at
2214 nm; dP1 and dP2 - pressure difference; M1
- granulation liquid consumption; AWA10 -
apparent water absorbance; Tdiff - temperature
difference (reprinted from Rantanen et al., 2001;
with permission from Elsevier)
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the specifi c variable in the mixing phase. Similarly, spraying and
drying phases can be found at the middle and top right corner of
the SOMs. Evolution of the granulation process can be studied
using the SOMs. Successful granulations were used to mark the
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