Biomedical Engineering Reference
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A model for redox and molecular recognition of flavin was proposed (Niemz and
Rotello, 1999). The redox behavior of flavin and its interaction with receptors, a series of
acylated diaminopyridines, in have been investigated using a combination of
cyclic voltampery, NMR, simultaneous electrochemistry and ESR, and UV/vis
electrochemistry. Variation of the acyl substituents enabled control of the host-flavin
recognition by modulation of both hydrogen bonding via change of acidity and
electrostatic through-space effects.
Below references are given which can provide a key to the relevant literature
concerning the mimicking of various reactions catalyzed by enzymes: (Shilov, 1997;
Iglesiasl998; Gust et al., 1999; Hegg et al., 1999; Wikaira et al., 1999; Silverman, 2000;
Kopf and Karlin, 2000; Hu et al., 2000; Ju et al., 2000; Naruta et al., 2001;
Hammarstrom et al., 2001; Ogliaro et al., 2001; Diekmann et al., 2002; and references
therein.).
In spite of marked benefits discovered in the field of modeling structure and action
mechanism of enzymes, more sophisticated models are needed to reach efficiency in the
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