Chemistry Reference
In-Depth Information
2
Structural and
Thermodynamic Studies
of
α
-Synuclein Proteins
Related to Parkinson's
Disease: Impact of
Aqueous Solution and
Fe
3+
Coordination
Olivia M. Wise, Liang Xu, and Orkid Coskuner
CONTENTS
2.1. Introduction..................................................................................................... 29
2.2. Methods........................................................................................................... 40
2.3. Results.and.Discussion.................................................................................... 50
2.4. Conclusion....................................................................................................... 75
References................................................................................................................ 77
2.1 INTRODUCTION
Parkinson's. disease. is. a. severe. neurodegenerative. disorder. that. currently. affects.
more. than. 1.5. million. people. in. the. United. States.. The. total. health. care. costs. for.
Parkinson's.disease.are.approximately.$25.billion.per.year,.and.this.cost.is.expected.
to.rise.unless.an.effective.treatment.can.be.found.
12
.For.an.eficient.treatment.to.be.
developed,.however,.the.cause.(molecular.mechanism).of.the.disease.must.irst.be.
determined. and. a. therapy. must. be. devised.. Often. the. most. effective. ways. to. dis-
cover. the. cause. of. any. disease. is. to. start. with. data. and. observations. from. those.
patients.already.presenting.symptoms.and.work.backward.through.the.progression.
of.the.disease.until.the.root.cause.is.exposed..A.thorough.understanding.of.what.is.
29
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