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the multiple potential approaches for its implementation o¨er novel oppor-
tunities for its use in the evaluation of immune interventions against AIDS and,
more generally, in vaccine research.
Acknowledgments. The work described in this chapter has been supported
by the Italian Project on AIDS (Ministero della SanitÁ ; Contract N. 10A/L,
1999). We are grateful to Cinzia Gasparrini and Anna Ferrigno for secretarial
assistance.
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