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now available (Matz et al., 1999). They will allow wider application of GFP for
¯uorescence resonance energy transfer ( FRET ) for the studies of viral protein
interaction with each other and with cellular proteins at di¨erent stages of viral
life cycles. Novel instrumentation for high-throughput cell imaging and ¯uo-
rescence detection will facilitate applications of ¯uorescent proteins in antiviral
drug development.
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