The Use of Peptide/MHC Tetramers to Visualize, Track, and Characterize Class I-Restricted Anti-HIV T-cell Responses - Cellular Aspects of HIV Infection - page 307

T A B L E 15.1. List of Published Epitopes That Have Been Used to Construct
Peptide/MHC Tetramers to Study HIV-1, SIV, EBV, and CMV Infection

Pathogen Protein Region Epitope HLA Allele Reference

HIV-1 p17 Gag A*0201 Dyer et al., 1999; Gray

et al., 1999; Spiegel
et al., 2000a, b;
Wilson et al., 1998;
Altman et al., 1996;
Ogg et al., 1998, 1999

SLYNTVATL

HIV-1 Pol A*0201 Dyer et al., 1999; Gray

et al., 1999; Spiegel
et al., 2000a, b;
Wilson et al., 1998;
Altman et al., 1996;
Ogg et al., 1998, 1999

ILKEPVHGV

HIV-1 Nef B8 Dyer et al., 1999;

Spiegel et al., 1999

FLKEKGGL

HIV-1 p17 Gag B8 Dyer et al., 1999

GGKKKYKLK

HIV-1 Env B35 Dyer et al., 1999; Ogg

et al., 1999

DPNPQEVVL

HIV-1 Pol EPIVGAETF B*3501 Dyer et al., 1999

HIV-1 p24 Gag KRWIILGLNK B*2705 Wilson et al., 2000

HIV-1 P24 Gag KRWIIMGLNK B*2705 Wilson et al., 1998, 2000

EBV LMP2 CLGGLLTMV A*0201 Jin et al., 2000

EBV BMLF1 A*0201 Callan et al., 1998;

Jin et al., 2000;
Ogg et al., 1999;
Tan et al., 1999

GLCTLVAML

EBV BZLF1 B8 Callan et al., 1998;

Tan et al., 1999

RAKFKQLL

EBV BZLF1 B8 Callan et al., 1998;

Tan et al., 1999

FLRGRAYGL

EBV EBNA3B A11 Tan et al., 1999

IVTDFSVIK

CMV pp65 A*0201 Jin et al., 2000; Spiegel

et al., 2000b

NLVPMVATV

CMV pp65

TPRVTGGGAM B*0702

Gillespie et al., 2000

SIVmac Gag Mamu-A*01 Egan et al., 1999

CTPYDINQM

SIVmac Pol Mamu-A*01 Egan et al., 1999

STPPLVRLV

HIV-1 Env Mamu-A*01 Egan et al., 1999

YAPPISGQI

SIV, simian immunode®ciency virus; EBV, Epstein-Barr virus; CMV, cytomegalovirus.

and Pol ( Kelleher and Rowland-Jones, 2000) ( Table 15.1). Although HLA-A2
is the most common HLA allele in Caucasians, it may not be common in other
regions of the world, where the majority of HIV-1 infections are found. Dif-
ferent HLA allele expression by HIV-1-infected people in these regions will
determine epitope selection (Gray and Puren, 2000) and will guide the con-