Alveolar Macrophages - Cellular Aspects of HIV Infection - page 213

T A B L E 10.2. Altered Human Alveolar Macrophage Function Associated with
HIV-1 Infection

Observed Alteration References

Alveolar macrophages from asymptomatic HIV-
infected individuals
Enhanced accessory cell function Twigg et al., 1989

Increased surface expression of class II MHC
molecules*

Buhl et al., 1993

Enhanced IL-1, IL-6 release Trentin et al., 1992; Sierra-

Madero et al., 1994

Dysregulated release of IL-8, IL-10, IL-12 Denis and Ghadirian, 1994a

Enhanced spontaneous release of superoxide anion y Buhl et al., 1993

Reduced P. carinii binding and phagocytosis Koziel et al., 1998a

Enhanced C. neoformans fungistasis Reardon et al., 1996

Reduced mannose receptor surface expression Koziel et al., 1998a

Reduced TNF-receptor I and TNF-receptor II
surface expression

Skolnik et al., 2000

Reduced oxidative burst response to P. carinii Koziel et al., 2000

Increased release of soluble mannose receptor Fraser et al., 2000

Alveolar macrophages from HIV-infected patients
with active disease
Enhanced S. aureus phagocytosis

Musher et al., 1990

Reduced P. carinii binding and phagocytosis Koziel et al., 1998a

Reduced mannose receptor surface expression Koziel et al., 1998a

Reduced TNF receptor I and TNF receptor II
surface expression

Skolnik et al., 2000

Reduced oxidative burst response to P. carinii Koziel et al., 2000

Enhanced TNF-a release Israel-Biet et al., 1991;

Krishnan et al., 1990;
Millar et al., 1991

Increased release of soluble mannose receptor Fraser et al., 2000

Enhanced GM-CSF release Agostini et al., 1992

In vitro HIV-1 infection of alveolar macrophages
from healthy individuals
Reduced P. carinii binding and phagocytosis Koziel et al., 1998a

Reduced mannose receptor surface expression Koziel et al., 1998a

Reduced C. neoformans fungicidal activity Ieong et al., 2000

Preserved anticryptococcal activity Cameron et al., 1990

Enhanced HIV-1 replication z Abbud et al., 1995

* Human leukocyte antigen (HLA)-DR, HLA-DQ, HLA-DP.
y

Noncultured cells.

z

Smokers compared with nonsmokers.