Information Technology Reference
In-Depth Information
exogenous and endogenous exposures that may influence the development of carcinoma
warrants further investigation of genetic polymorphisms at xenobiotic metabolizing loci
and analysis of gene-gene and gene-environment interactions in large series of patients.
References
>1@ http://www.snp.cshl.org
>2@ Ingelman-Sundberg, M. (2001) Genetic variability in susceptibility and response to toxicants. Toxicol
Letts 120, 259-268
>3@ Nebert, D.W. et al. (1999) Genetic epidemiology of environmental toxicity and cancer susceptibility:
human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and
nomenclature issues. Drug Metabol. Reviews 31, 467-487.
>4@ Miller, M.C. et al. (2001) Genetic variability in susceptibility and response to toxicants. Toxicol. Letts.
120, 269-280
>5@ Gemignani, F. et al. (2002) A catalogue of polymorphisms related to xenobiotic metabolism and
cancer susceptibility. Pharmacogenetics 12, 459-463
>6@ Thompson, P.A. and Ambrosone, C. (2000) Molecular epidemiology of genetic polymorphisms in
estrogen metabolizing enzymes in human breast cancer. J Natl. Cancer Inst. Monographs 27, 125-134.
>7@ Yager, J.D. and Liehr, J.G. (1996) Molecular mechanisms of estrogen carcinogenesis. Ann. Rev.
Pharmacol. Toxicol. 36, 203-232.
>8@ http://www.imm.ki.see/CYPalleles /cyp1b1.htm
>9@ Fritsche, E. et al. (1999) Detection of Cytochrome P450 1B1 Bfr I polymorphism: genotype
distribution in healthy German individuals and in patients with colorectal carcinoma.
Pharmacogenetics 9, 405-408.
>10@ Lachman, H.M. et al. (1996) Human Catechol-O-methyltransferase pharmacogenetics: description of a
functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics
6, 243-250
>11@ Shimoda-Matsubayashi, S. et al. (1996) Structural Dimorphism in the Mitochondrial Targeting
Sequence in the Human Manganese Superoxide Dismutase Gene. Biochem. Biophysical Res.
Commun. 226, 561-565.
>12@ Bell, D.A. et al. (1993) Genotype/ phenotype discordance for human arylamine N-acetyltransferase
(NAT2) reveals a new acetylator allele common in African-Americans. Carcinogenesis 14, 1689-1692.
>13@. http://www.louisville.edu /medschool/pharmacology/NAT.html
.
