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b )
Figure 18. a) flavodoxin, 1flv [71].
CATH
: 3,40,50,360 (Alpha beta, 3-layer (aba)
Sandwich, Rossman fold)
SCOP
: a/b favodoxin-
like. b) Topology
a )
a)
b)
Figure 19. a) Ubiquitin, 1ubi [76]. Example of a UB roll.
CATH
: 3,10,20,90. (alpha
beta, roll, UB roll).
SCOP
: a+b, beta-grasp (ubiquitin-like). b) Topology: ββα motif
Alpha + Beta Domains Alpha + beta folds are more diverse than either
α
or
α
/
β
folds and contain many complex folds which cannot be easily clustered into groups.
However there are two super-folds in this class made up of repeated
ββα
units, which form
an open anti-parallel or mixed
-sheet with helices on each side.
UB (Ubiquitin) roll The UB roll is an open twisted
β
-sheet with
αβ
Greek-key
topology (
β
ββαβ
) packed against
α
-helices. Examples include ferredoxin and protein G [72-
73].
-sheet packed against
α
-helices to form a two-layered sandwich containing the
αβ
Greek-key motif (
βαββ
).
Examples include phosphotransferase and chorismate mutase [74-75].
Plaitfold The plaitfold is similar to the UB roll comprising a
β