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A
B
C
Figure 13
: Analysis of breakpoint sequences in human
chromosomal DNA
A:
Flexibility of DNA obtained
from conformational energy calculations, expressed as
dinucleotide twist, roll and tilt angles. Thick arrow:
breakpoint. (plot.it server)
B.
Twist angles in a
sequence 40 bp, determined from NMR data (empty
circles), and as predicted based on conformational
energy calculations. Thick arrow: breakpoint. (plot.it
server)
C.
Predicted 3-D model of the short breakpoint
motif CCAGCCTGG, built by the model.it server using
the consensus scalel of DNA curvature, and the raw
models being refined by simulated annealing (model.it
server).
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