Chemistry Reference
In-Depth Information
Table 3.3 Main randomized Controlled Clinical studies using Fructan Prebiotic In Prevention or Treatment of Acute Diarrhea
Prebiotic Type,
Consumption
Method/end
Points
subjects
study Design
Main results
ref.
indonesian well-nourished male
infants, aged 3-12 months,
acute diarrhea with moderate
dehydration
n
= 58
randomized
double-blind
clinical trial
special infant formula
containing probiotic,
prebiotic, and
supplements
a
vs.
control
duration of
diarrhea
diarrhea signiicantly shorter in
the study group than in the
control group (1.63 vs. 2.45
days;
p
< 0.05).
agustina
et
al., 2007
infants in a community with a high
burden of gastrointestinal and
other infections
n
= 282
randomized
controlled trial
1
infant cereal
supplemented with
oligofructose (0.55
g/15 g cereal) or not
supplemented
duration of
diarrhea
Mean (± sd) days of diarrhea
were 10.3 ± 9.6 in the
nonsupplemented cereal group
and 9.8 ± 11.0 in the prebiotic-
supplemented cereal group (
P
= 0.66).
duggan
et
al., 2003
infants in a community with a high
burden of gastrointestinal and
other infections
n
= 349
randomized
controlled trial
2
Zinc (1 mg/15 g cereal)
added to both
oligofructose-
supplemented and
nonsupplemented
cereals
duration of
diarrhea
Mean days of diarrhea were
10.3 ± 8.9 in the group
consuming cereal fortiied only
with zinc and 9.5 ± 8.9 in the
group consuming cereal
containing both zinc and
prebiotics (
P
= 0.35).
Consecutive inpatients with
C.
difficile-
associated diarrhea
n
= 142
randomly
allocation
oligofructose or placebo
for 30 days in addition
to speciic antibiotic
treatment
Prevention
of further
diarrhea
relapse of diarrhea was
observed in 34% with placebo
and 8% with oligofructose (
P
<
.001).
Lewis
et al.,
2005
Healthy subjects, traveling to
high- and medium-risk destinations
for travelers' diarrhea
n
= 244
randomized,
double-blind,
placebo-
controlled
study
10 g fos or placebo
daily for 2 weeks
before travel
Prevention
of further
diarrhea
11.2% in fos group and 19.5%
in placebo (
p
= 0.08)
diarrhea severity score was
lower in fos than in placebo
groups (
P
< 0.05)
Cummings
et
al., 2001
a
special antidiarrhea infant formula containing probiotic (
Lactobacillus rhamnosus
LMg P-22799; 5 × 10
8
colony-forming units/100 mL), prebiotic
(inulin 0.15 g/100 mL), iber (soy polysaccharides: 0.2 g/100 mL), and iron + zinc.
