Chemistry Reference
In-Depth Information
Table 17.1
In Vivo
Experiments (In Chronological order beginning in 2005), reporting Effects of Prebiotics in Cats and Dogs (continued)
Animals/
Treatment (Age,
initial bW)
outcome variables
Quantiied
Dietary Information; Time
on Treatment
Daily Prebiotic Dose;
source
ref.
Major Findings
Middelbos et
al., 2007
12
apparent ileal and
total tract nutrient
digestibility
5 purpose-bred
adult female dogs
(4 yr of age; 23
kg bW)
280 g basal diet
0 g supplementation
↑
ileal nutrient digestibility (10%
dM, 11% CP)*
Chemical composition:
30% CP
21% fat
4% tdf
0.07 g yCW/d
Linear
↓
in monocyte counts
(control: 1.0 thousands/μL vs.
0.65% supplementation: 0.7
thousands/μL)**
serum iga, igM,
and igg
0.35 g yCW/d
0.63 g yCW/d
fecal microbial
populations
time on treatment: 14 d
0.91 g yCW/d
(safmannan, Lesaffre
yeast Corporation,
Milwaukee, Wi)
Linear
↓
in fecal
E. coli
populations (control: 9.1 cfu/g
fecal dM versus 0.65%
supplementation: 8.2 cfu/g
fecal dM**)
respondek et
al., 2008
9
euglycemic
hyperinsulinemic
clamp
8 beagle dogs (6.5
years; 12.8 ± 1.3
kg)
obese dogs
basal diet chemical
composition:
29.4% CP
18.6% fat
days on treatment: 6 wk
1% w/w of dM intake
(Profeed, béghin-Meiji,
Marckolsheim, france)
↑
rate of glucose infusion (7.8
vs. 4.7 mg/kg/min)**
↑
adipose tissue uCP 2 gene
expression (~39%)**
↑
adipose tissue CPt1 gene
expression (~32%)*
adipose tissue gene
expression
Note:
bCs, body condition score; bW, body weight; CPt1, carnitine palmitoyl transferase; Cf, crude iber; cfu, colony-forming units; CP, crude protein;
dgge, denaturing gradient gel electrophoresis; dM, dry matter; fos, fructo-oligosaccharide; iga, immunoglobulin a; ige, immunoglobulin e; igg,
immunoglobulin g; igM, immunoglobulin M; Mos, mannanoligosaccharides; n, nitrogen; sCfa, short-chain fatty acids, scfos, short-chain fructo-
oligosaccharides; tdf, total dietary iber; uCP2, uncoupling protein 2; yCW, yeast cell wall.
*
P
< 0.10.
**
P
< 0.05.
***
P
< 0.001.
