Chemistry Reference
In-Depth Information
Table 16.2 selected recent Probiotic Clinical Trials with Elderly Individuals
subjects, study groups, and
Doses
a
Probiotic
study Design
b
Effects
ref.
Biidobacterium lactis
Hn019 in
skim milk
age 60-87 (mean 69.5 years)
Placebo:
n
= 20
Low dose: 6.5 × 10
7
/day,
n
= 20
Medium dose: 1 × 10
9
/day,
n
= 20
High dose: 5 × 10
9
/day,
n
= 20
2 week run-in,
4-week feeding
with three
different doses,
2-week
wash-out
increase of fecal biidobacteria,
lactobacilli, and enterococci and
decrease of enterobacteria with
all three probiotic doses
ahmed et
al.
24
B. longum
46 and 2C or
B. lactis
bb12 in fermented oat drink
age 61-102 years (mean 84),
nursing home residents
Placebo:
n
= 51
group 1:
B. longum
10
9
/day,
n
= 46
group 2:
B. lactis
10
9
/day,
n
= 82
3 months run-in,
6-month feeding
period
normalizing effect on bowel
movements (relief of
constipation, diarrhea, and other
intestinal problems) in both
probiotic groups
Pitkälä et
al.
25
Lactobacillus johnsonii
La1 in
fermented milk
age 75-96 years (mean 85),
hospitalized, enterally fed
Placebo:
n
= 12
Probiotic: 10
9
/day,
n
= 12
12 weeks run-in,
12-week feeding
period
decrease in the percentage of
days with infections, increased
blood Hb
fukushima
et al.
26
L. casei
dn-114001,
Streptococcus thermophilus,
and
L. bulgaricus
in yogurt
drink
Mean age 74 years, hospitalized,
taking antibiotics
Placebo: sterile milkshake,
n
= 66
Probiotic: 10
10
/day of each strain,
n
= 69
feeding during a
course of
antibiotics and 1
week after the
course inished
decrease in the incidence of
antibiotic and
C. difficile-
associated diarrhea
Hickson et
al.
27
L. rhamnosus
gg and Lc705
and
P. freudenreichii
Js in
cheese
age 70-100 years
Placebo: n = 140
Probiotic: 5 × 10
8
/day of each
strain, n = 136
3 week run-in,
16-week feeding
period
reduced the risk of high yeast
counts and hyposalivation
Hatakka et
al.
28
a
unless otherwise indicated, the placebo was the same product without the probiotic.
b
all trials were randomized, double-blind, and placebo-controlled.
