Chemistry Reference
In-Depth Information
Table 15.1 Clinical Trials with Prebiotic oligosaccharides in Term Infants (Nutritional Intervention During the First year of life)
(contin
ued)
Target group/
Completers in
Prebiotic group
Prebiotic
Compound
Age
(months)
Main outcome
ref.
scgos/lactulose
0-6
Healthy infants/150
softer stools and increased stool frequency (no microbiology)
Ziegler et al.
86
scfos/inulin
0-12
Healthy infants/24
increased postvaccination igg measles antibody plasma levels
firmansyah et al.
87
aos + scgos +
lcfos
0-6
Healthy infants/31
increased counts of biidobacteria with gos/fos/aos, decreased
fecal pH
fanaro et al.
88
aos + scgos +
lcfos
0-6
Healthy infants/49
biidogenic, in particular if aos are present
Magne et al.
89
scgos + lcfos
0-5
infants with
constipation/20
reduced hardness of stool (no microbiology)
bongers et al.
90
scgos + lcfos
0-4
Healthy infants/56
increased counts of biidobacteria and lactobacilli, decreased fecal
pH, effect dose dependent
Moro et al.
91
Moro et al.
92
scgos + lcfos
0-6
Healthy infants/28
increased counts of biidobacteria, softer stools
schmelze et al.
93
scgos + lcfos
0-6
Healthy infants/21
increased counts of biidobacteria and lactobacilli, dominance of
B.
infantis
, short-chain fatty acid pattern like breastfed infants
knol et al.
94
Harman et al.
95
Harman et al.
96
scgos + lcfos
0-3
Healthy infants/34
trend for higher counts of biidobacteria, reduced counts of clostridia
Costalos et al.
97
scgos + lcfos
9-12
infants with minor
gastrointestinal
problems/604
reduction of gastrointestinal problems (no microbiology)
salvino et al.
98
scgos + lcfos
9-12
infants with minor
gastrointestinal
problems/55
reduction of gastrointestinal problems (no microbiology)
salvino et al.
99
scgos + lcfos
4-12
infants at weaning/10
increased counts of biidobacteria
scholtens et al.
100
