Chemistry Reference
In-Depth Information
treated group, but no difference in bloating was reported between the groups.
101
The
same formula was applied in a cross-over trial of 4 weeks duration in 12 patients.
A significant reduction in breath hydrogen was registered after 2 hours of ingestion,
without a change in total hydrogen production or any symptomatic improvement.
103
A total of 68 patients with IBS were treated for 12 weeks with a vitamin and plant
fiber-enriched diet containing either live or heat-inactivated LAB including 10
9
each
of
L. acidophilus
,
L. helveticus,
and
Bifidobacterium
spp.
104
Of the patients, 80 and
40 percent, respectively, reported significant improvements in pain, bloating, consti-
pation, and bowel habits (
p
< 0.01).
8.10.8 synbiotics in
Helicobacter pylori
Infections
A clinical trial was carried out in a school in a low socioeconomic area of
Santiago, Chile.
Helicobacter pylori
(Hp) positive children were randomly distrib-
uted into four groups: (1) antibiotic treatment (lanzoprazole, clarythromycin, and
amoxicillin) (Ab) daily for 8 days; (2) 250 mg
Saccharomyces boulardii
plus 5 g
inulin (SbI) daily for 8 weeks; (3) 1 billion
L. acidophilus
LB (LB) daily; or (4) no
treatment.
105
A
13
C-urea breath test (
13
C-UBT) was performed before and after the
study and the differences in
13
CO
2
over baseline were calculated (DDOB). Hp was
eradicated in 66, 12, and 6.5 percent of the children from the Ab, SbI, and LB groups,
respectively, while no spontaneous clearance was observed in the children without
treatment. A moderate but significant difference in DDOB was detected in children
receiving living SbI (76.31; 95 percent CI: 711.84 to 70.79), but not in those receiving
LB (+0.70; 95 percent CI: 75.84 to +7.24). Although more studies are needed to con-
firm the effects and elucidate the mechanisms, it is clearly an interesting observation
that Hp infection was eradicated in 12 percent of synbiotic-treated and 6.5 percent of
probiotic-treated Hp-infected children. It is likely that other LAB and larger doses of
both LAB and prebiotics might achieve much stronger effects.
8.10.9 synbiotics in Allergy
A synbiotic combination of
L. casei
subsp.
casei
+ dextran prevented cedar pol-
len-induced nasal and ocular symptoms, increased cedar pollen-specific IgE, and
increased the number of eosinophils.
106
In another randomized study, children > 2 years with atopic dermatitis received
either potato starch and
L. rhamnosus
-based synbiotics or the prebiotic alone three
times a day for 3 months. The disease score decreased with synbiotic treatment from
39.1 to >20.7 (
P
< 0.0001), and with prebiotic treatment from 39.3 to 24.0 (
P
< 0.0001).
No difference was observed after 3 months of treatment (
P
= 0.535).
107
8.10.10 synbiotics in Prevention of Cancer
A synbiotic preparation consisting of oligofructose-enriched inulin (12
g) (SYN1),
L. rhamnosus
GG (LGG), and
B. lactis
Bb12 (BB12) (10
10
cfu), was
recently administered in a 12-week randomized, double-blind, placebo-controlled
