Chemistry Reference
In-Depth Information
•
Angiotensin/rennin.
It is well documented that release of angiotensin is signifi-
cantly associated with oxidative stress, increased levels of free fatty acids in serum,
and with reduction in beta cell function in diabetes.
39 - 41
Recent studies demonstrate
that blockage of the angiotensin receptor will reduce production and accumulation
of AGE both
in vitro
and
in vivo
.
41
Larger intake of glutenoids.
•
Glutenoids are increasingly regarded as proinflamma-
tory in the body (Tlaskalová-Hogenová H, personal communication), even in the
absence of intestinal changes.
42,43
Low intake of plant antioxidants
•
•
High intake of carbohydrates
•
High intake of saturated and trans-fatty acids.
A strong association has repeatedly
been documented between the average content of fat in food and the morbidity and/
or mortality in chronic diseases in a country, as demonstrated for breast cancer in
Figure 7.3,
44
but also reported for various other cancers and chronic diseases such
as coronary heart disease
45,46
and diabetes.
47
As more than three-fourths of the con-
sumed saturated fat is of bovine origin, similar curves are also reported that corre-
late amount of intake of dairy products to incidence of various chronic diseases.
48
NETHERLANDS
25
UK
DENMARK
NEW ZEALAND
CANADA
Female
SWITZERLAND
U.S.
IRELAND
BELGIUM
20
AUSTRALIA
GERMANY
FRANCE
AUSTRIA
NORWAY
ITALY
15
CZECH
FINLAND
PORTUGAL
HUNGARY
HONG KONG
CHILE
POLAND
10
BULGARIA
SPAIN
VENEZUELA
ROMANIA
YUGOSLAVIA
GREECE
PANAMA
PUERTO RICO
COLOMBIA
5
PHILIPPINES
MEXICO
JAPAN
TAIWAN
SRI LANKA
THAILAND
EL SALVADOR
0
0 20 40 60 80 100 120 140 160 180
To tal dietary fat intake (g day
-1
)
Figure 7.3
Mortality in breast cancer in a country related to the mean intake of saturated fat
in the same country. (adapted from Carroll, 1975.
44
)
