Biomedical Engineering Reference
In-Depth Information
chors. The other two components of the SMA body, the “A” and “B” blocks,
play the roles of affinity ligands and supporting spacer-arms. The spacers
are enrolled with hydrophilic and flexible oligomer chains, typically PEGs.
The ligands are immobilized as endgroups of the spacers, the selection of
which depends on the required biofunctional specialties. The coordination
between SMA endgroups and spacers is responsible for efficient commitment
of the endgroup ligands to their corresponding receptors on the target biolog-
ical counterparts. The modified polyurethane surfaces are used as a platform
for assessments of selective protein adsorption, blood-contacting compatibil-
ity, and vascular cell hybridization. Accordingly, superior efficacies have been
demonstrated by the surface modification on albumin-selective binding, bio-
compatibility, and engineered endothelialization. Additionally, the technical
simplicity of these strategies illuminates a bright perspective for delivery to
practical uses.
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