Biomedical Engineering Reference
In-Depth Information
Functional Materials Derived from DNA
Xiang Dong Liu
1
· Masanori Yamada
2
·MasajiMatsunaga
1
·
Norio Nishi
1,3
(
)
1
Nissei Bio Co., Ltd, Megumino, Eniwa, 061-1374 Hokkaido, Japan
nishin@ees.hokudai.ac.jp
2
Faculty of Science, Okayama University of Science, Ridaicho, 700-0005 Okayama, Japan
3
Graduate School of Engineering, Hokkaido University, Kita-ku, 060-8628 Sapporo,
Japan
1
I tr cti n
...................................
150
2
Helical Anionic Polymer
............................
152
2.1
DNAandInorganicMatters ..........................
153
2.2
DNAandCollagen................................
155
2.3
DNAandCationicLipids............................
156
3
DNA Strand Pairing
...............................
158
3.1
DNANanostructure...............................
158
3.2
DNA-MediatedMolecularStructures......................
161
3.3
DNADevice ...................................
163
4
Double Helix Binding
..............................
165
5
i ly er
...................................
171
6
Perspective
....................................
174
References
.......................................
175
Abstract
DNA has special properties and its unique double-helical structure offers excel-
lent prospects for creating novel DNA-based materials. In recent years, DNA has been
shown to be an ideal molecule in the material world. This review is intended to provide
an overview of functional materials derived from DNA based on the double-helical struc-
ture. Various DNA-based materials are reviewed according to the basic DNA structural
properties, including the electrostatic properties of DNA as a highly charged polyelec-
trolyte, complementary base pairing, and intercalation and groove binding interaction
with small molecules. Finally, attempts to produce biomaterials based on DNA are also
summarized.
Keywords
DNA binder
·
Double-helical structure
·
Intercalation
·
Molecule device
·
Nanostructure
Abbreviations
dsDNA Double-stranded DNA
ssDNA
Single-stranded DNA
