Biomedical Engineering Reference
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a
Striatal expression of
g
subtypes
800.0
700.0
600.0
500.0
400.0
300.0
200.0
100.0
0.0
Gng2
Gng3 Gng4 Gng5 Gng7 Gng10 Gng11 Gng12 Gng13
b
Striatal abundance of
g
subtypes
3.5
3.0
2.5
2.0
1.5
1.0
0.5
0.0
γ
2
γ
3
γ
7
γ
5
Fig. 10.2
Unique requirement for G-g
7
subunit is not related to expression or abundance.
(
a
) Striatal neurons expressing the D
1
dopamine receptor (
open bars
) or the D
2
dopamine and A
2a
adenosine receptors (
closed bars
) express different G-g mRNA transcripts (Data derived from
Doyle et al.
2008
) . (
b
) In striatum, the G-g
2
subtype is the predominant form as measured by quan-
titative immunoblot analysis and expressed as ng g protein per m g membrane protein
References
Andresen BT (2011) A pharmacological primer of biased agonism. Endocr Metab Immune Disord
Drug Targets 11(2):92-98
Balcueva EA, Wang Q, Hughes H, Kunsch C, Yu Z, Balcueva RJD (2000) Human G protein g
11
and
g
14
subtypes define a new functional subclass. Exp Cell Res 257(2):310-319
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