Biomedical Engineering Reference
In-Depth Information
Chapter 6
Regulated GPCR Trafficking to the Plasma
Membrane: General Issues and the CCR5
Chemokine Receptor Example
Hamasseh Shirvani , Gabriel Gätà , and Stefano Marullo
Contents
6.1 Introduction.....................................................................................................................
98
6.2
Historical Background of a New Concept ......................................................................
98
6.3 Accessory Proteins Promoting GPCR Forward Export or Involved in
Their Cytoplasmic Retention .......................................................................................... 101
6.4 The CCR5 Chemokine Receptor..................................................................................... 104
6.5 Conclusions..................................................................................................................... 107
References ................................................................................................................................ 108
Abstract
The regulated export of nascent G protein coupled receptors (GPCRs)
from intracellular stores is an emerging concept with important implications in cell
biology and pharmacology. This phenomenon requires a complex network of inter-
actions between GPCRs with either chaperones and escort proteins or gatekeepers,
which are respectively involved in the progression of GPCRs along the biosynthetic
pathway to the plasma membrane or in their retention in intracellular compartments.
The regulated export of GPCRs is also controlled by external stimuli and might
represent an adaptive mechanism to specific physiological constraints, such as the
sustained activation of the CCR5 chemokine receptor in the context of chemotaxis.
Keywords
GPCR Chaperone Escort protein Secretory pathway Resensitization
Gate-keeper CCR5 CD4
Search WWH ::
Custom Search