Chemistry Reference
In-Depth Information
(H
2
O)
2
O
O
G
d
O
O
N
O
N
N
O
O
O
O
O
(OH
2
)
2
O
O
O
O
N
O
O
Gd
(H
2
O)
2
N
N
N
O
N
N
O
N
N
O
O
O
N
N
N
N
O
O
N
O
N
OH
O
O
HO
N
O
OH
HO
O
O
O
HO
O
OH
O
O
O
O
O
HO
O
O
N
OH
O
N
O
N
N
N
N
N
N
Gd
(OH
2
)
2
HO
N
O
OH
N
(H
2
O)
2
O
O
N
OH
HO
OH
O
HO
N
O
O
O
O
O
O
O
O
O
O
N
N
N
N
N
N
O
O
O
O
N
O
O
N
N
N
N
O
O
O
O
N
O
Gd
Gd
O
O
(OH
2
)
2
O
O
(H
2
O)
2
O
76
FIGURE 12.21
The paramagnetic
-cyclodextrin click cluster.
12.6 CONCLUSION AND FUTURE PERSPECTIVE
Carbohydrates constitute a major class biomolecules lying inside or on the surface
of cell and govern several pathologically and physiologically vital biological events
such as cellular recognition, adhesion, migration, invasion, communication, bacte-
rial/viral infection, tumor metastasis, post-translational modifications of protein etc.
Therefore, it is challenging to craft glycoconjugates, which can fulfil the objective
of understanding role of carbohydrates in these pivotal interactions and also regulate
these processes majorly by acting as inhibitors of those enzymatic transformations.
Several 1,2,3 triazole core containing drug like molecules with good pharmacokinetic
properties have been synthesized, however, there is lot more to explore about this vast
pool of triazolyl glycoconjugates. The triazole forming click reaction promisingly
facilitates creation lead and its optimization due to its modular nature, reliance on
extremely short sequences of near-perfect reactions. Therefore, it's time to recognize
Search WWH ::
Custom Search