Chemistry Reference
In-Depth Information
SCHEME 12.4
Sugar arrays synthesized
in situ
in the microtiter plate.
of radioisotopes capable of imaging these specific events
in vivo
. In recent years, the
discovery of new biological targets has imposed the development of innovative and
efficient methodologies that can ensure a firm attachment of molecules of biomed-
ical interest to readily available radionuclides having suitable decay characteristics.
Bryson et al. synthesized a novel contrast agent,
-cyclodextrin click cluster (
76
)
for macromolecular Magnetic Resonance Imaging (MRI). The cluster consisting of
seven paramagnetic arms with two water exchange sites each (Fig. 12.21) can exert
an exceptionally high relaxivity profile (43.4 mM
−
1
s
−
1
at 9.4 T) at high magnetic
field and enhances contrast on a human MRI scanner. Moreover, the useful inclusion
properties exhibited by
-cyclodextrin also makes this an excellent host scaffold to
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