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N
N
OH
HO
CF
3
N
HO
O
N
N
HO
O
N
OMe
OH
HO
OH
4
(CH
2
)
n
CH
3
N
N
OH
OH
HO
N
O
H
O
O
HO
HO
N
N
O
HO
N
(CH
2
)
13
CH
3
OH
NHAc
OH
7
n
= 5, 6, 15, 22, 23, 24
6
FIGURE 12.4
Biologically active Glycosylated Triazoles.
Campo et al. explored CuAAC-assisted cyclo-oligomerization of isomeric azido-
alkyne derivatives of
-D-galactopyranose and obtained dimeric to pentameric cyclic
pseudo-oligosaccharide macrocycles, which were subsequently examined for their
compatibility with enzymatic sialylation by
Trypanosoma cruzi trans-sialidase
,in
search of potent inhibitors against the enzyme. The bifunctional galactose precursors
N
Ar
O
OAc
N
N
N
O
AcO
AcO
O
N
O
OAc
8
OH
O
N
N
O
N
R
O
O
BzO
R = Ar, CH
2
Ar
9
FIGURE 12.5
Biologically active Triazoles.
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