Chemistry Reference
In-Depth Information
SCHEME 11.12
The
structure
of
“click”
copolymer
of
-CD
and
dialkyne-oligo-
ethyleneamines. (Adapted from ref. 37.)
As another interesting approach, Mendez-Ardoy et al. developed a family of
discrete and well-characterized amphiphilic polycationic
-CD “click” clusters as
gene delivery vehicles (Scheme 11.13). The cationic structure for DNA complexation
was first installed on the primary hydroxyl group of
-CD by “click” HDC reaction.
Hydrophobic tails were then conjugated to the secondary hydroxyl group. Such CD-
centered amphiphilic compounds could self-assemble and complex with pDNA. By
tuning the density of positive charges, their distance to the CDs' core and the length
N
N
N
N
N
N
N
N
N
X
X
N
N
N
N
N
N
N
N
N
N
+
N
N
+
N
N
N
N
O
RO
X=NH
3
Cl
OR
O
7
SCHEME 11.13
Representative structure of
-CD-based “click” cluster for gene delivery.
(Adapted from ref. 38.)
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