Chemistry Reference
In-Depth Information
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SCHEME 11.7
Representative structure of the “click” CD hydrogel. (Adapted from ref. 24.)
11.3.2.3 Functional Biomedical Polymers
Poly(vinylidene fluoride) (PVDF) is
an important biopolymer due to its unique piezoelectric, ferroelectric, and dielec-
tric properties, good biocompatibility, and excellent membrane-forming capability
[25, 26]. For many of its potential biomedical applications, it is critical to be able to
manipulate and control the surface properties of PVDF. Recently, Cai et al. prepared
PVDF-g-PPMA copolymers bearing pendent propargyl functionalities by thermally
induced graft copolymerization of propargyl methacrylate (PMA) from the ozone
pre-activated PVDF backbones [27]. By phase inversion in aqueous media, microp-
orous membranes with pendent propargyl functionalities were then fabricated from
the functionalized PVDF, which would serve as a “clickable” platform for further
tailoring of the surface functionalities. Catalyzed by CuBr, azido-
-CD reacted with
the grafted propargyl groups to give the PVDF-g-P[PMA-“click”-
-CD] membrane.
After complexation with the adamantyl group of diadamantyl-poly(ethylene oxide)
(DA-PEO) guest polymer, the modified membrane exhibited good resistance to pro-
tein adsorption and fouling under continuous flow conditions.
The unique hydrophobic annulus structure of CDs affords them with the capability
to complex with a variety of different low-molecular-weight hydrophobic molecules.
Such capacity is very important in food industry in terms of protecting lipophilic food
components, stabilize fragrances, flavors, and especially suppress unpleasant odor or
bitter taste. It is well known that flavonoids (such as naringin and neohesperidine)
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