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OR
1
OR
1
H
N
N
N
N
Zn
N
N
N
R
1
O
OR
1
R
1
O
R
1
=CH
2
-C
CH
OR
1
OR
2
R
1
=(CH
2
)
3
N
3
OR
2
H
N
N
N
N
Zn
N
N
N
OR
2
OR
2
R
2
O
R
2
O
OH
OH
H
H
OR
3
HO
H
O
O
HO
R
3
=
HO
HO
HO
N
H
R
2
=
H
H
OH
N
N
H
H
O
R
3
N
N
R
2
=
N
N
R
2
=
N
N
OR
3
FIGURE 1.3
Porphyrin-based constructs synthesized by Maillard et al.
the tetrapeptide, Arg-Gly-Asp-Cys (RGDC) substituted with the propargyl group
gave the highest yield. The synthetic strategy is shown in Figure 1.4.
1.3 COUPLING USING THIOL-ENE COUPLING CLICK CHEMISTRY
In recent years, another reaction, thiol-ene coupling (TEC), joined the exclusive club
of click chemistry processes [17-19]. It is worth noting that the TEC reaction has
been known for more than 100 years [20]. The addition of thiols to simple alkenes
(and alkynes) is almost always free radical and can be initiated either thermally or
photolytically.
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