“SWEET” SUCROSE MACROCYCLES VIA A “CLICK CHEMISTRY” ROUTE - Click Chemistry in Glycoscience: New Developments and Strategies - page 229

N

R'

+

N +

R''

N -

1 2

R''

N

N

N

R''

N

N

N

R'

R'

1,4-adduct 1,5-adduct

FIGURE 9.1 The general scheme of Huisgen reaction.

Cu(I)-modified zeolites (offering stabilized Cu(I) species which may exclude the
formation of undesirable alkyne homocoupling products [8]) can be successfully
applied, also for complex products such as carbohydrate derivative 3 (Fig. 9.2) [9].
The click chemistry approach quickly became a standard methodology of cou-
pling, in a predictable way, two molecules (fragments) in various fields of organic,

COOEt

N

N

N

OMe

COOEt

O

O

O

N

SPh N

N

OMe

3

FIGURE 9.2 Double functionalized sugar block by “click” approach.