Chemistry Reference
In-Depth Information
O
O
N
O
O
O
Br
N
O
O
N
+
+
Si
O
O
52
59
O
Cl
60
N
N
O
a)TBAF, AcOH, THF
b) N-(ethyl)-2-pyridylmethanimine
CuBr, toluene
O
O
O
N
Br
O
x
y
O
O
O
O
O
retro Diels-Alder
O
N
coclick with
2-azidoethyl
glycosides
N
protein-SH
conjugation
N
O
O
Cl
N
O
N
61
O
O
N
O
BSA
S
x
Br
y
m
O
O
O
O
O
O
O
OH
N
OH
N
HO
HO
O
N
N
N
N
N
OH
HO
O
N
O
O
HO
O
OH
Cl
62
N
O
N
SCHEME 6.10
Synthesis of BSA-conjugated fluorescently-labelled click heteroglyco-
polymers.
were able to significantly activate the complement system via the lectin pathway,
a powerful arm of the circulating immune system [105]. Other click glycopolymer
applications explored include the inhibition of the interactions of a human den-
dritic cell-associated lectin and the viral envelope glycoprotein gp120, involved in
HIV infection [106], the preparation of bead-immobilized glycopolymers for their
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