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(a)
Lipid-binding
Protein
Lipid-binding
Protein
Protein labeling
and enrichment
N
Protein
Identification
N 3
N
N
(b)
-2
O
O
O
O
OPO 3
-2
OH
P
O 3 PO
O
P
O
P
O
O
O
O
R
N
O
N
O
O
O
O
O
NH 3
O
-2
N
O 3 PO
O
P
O
O
O O
O
O
P
O
O
6
OH
F
O
O
O O
O
16
O
15
5
14
10
10
NH
N 3 N 3
36a
O
38
O
HN
35a-b
O
H
O
P
O
N 3
N
O
O
a :R 1 =
O
O
O
O
F
P O
16
b :R 1 =
15
O
37
36b
FIGURE 4.9 The development of activity-based lipid probes. (a) Cartoon depicting the application of lipid activity probes for the labeling and
identification of target proteins. (b) Examples of lipid activity probes that have been reported. (See color plate section.)
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