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O
O
HO
a: R 2 =
O
e: R 2 =
COOH
N
O
b: R 2 =
O
S
1)
NHR 2
O
N HN R 2
17a-g
N
N
R 1 O
N 3
O
O
N
O
N
CuSO 4
R 1 O
c: R 2 =
sodium ascorbate
O
O
f: R 2 =
O
O
O
THF / H 2 O
SO 3
O
16
O
O
16
O
O
2) introduce azide
(for 20g only)
16
16
O
S O
d: R 2 =
3) deprotect phosphate
(for 20a d,f g )
16 :R 1 =H
19 :R 1 = P(O)OBn 2
18a e :R 1 =H
20a d,f g :R 1 =PO 3 -2
--
-
--
O
NHR 3
17g :R 3 =H
20g :R 3 =
O
g: R 2 =
N 3
O
H
O
O
FIGURE 4.5
Functionalized DAG and PA probes accessed through CuAAC.
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