Biology Reference
In-Depth Information
Fig. 10.3 The U -manipulated
version of the selection
diagram in Fig. 10.2
I
U
E
C
S
A
Theorem 3. Let D be the selection diagram characterizing two populations,
and
Π
P ð
*, and S the set of selection variables in D. The causal effect R
¼
y
j
do
ð
x
ÞÞ
Π
can be extrapolated from
* if and only if the expression P ( y | do ( x ) ,S ) is
reducible, using the rules of do-calculus, to an expression in which no do-operator
is conjoined with S. (Pearl and Bareinboim 2011 , p. 32)
to
Π
Π
As noted above, the causal effect of X upon Y , represented by the formula P
,
is the probability distribution of Y conditional on an intervention on X .Aninterven-
tion or manipulation on X is an exogenous cause that targets X alone and eliminates
all other causes of X . To illustrate, consider the U -manipulated version of the
selection diagram from Fig. 10.2 (i.e., the version of that diagram resulting from an
intervention on the variable U ). As shown in Fig. 10.3 , this modified selection
diagram eliminates the confounding arcs and adds a new variable labeled I ,
representing the intervention, with an arrow pointing directly into U . The do-calculus
consists of three basic rules, derived from the Markov condition, for manipulating
probabilities that contain do -operators, such as do ( x )(Pearl 2000 , pp. 85-86).
To understand Theorem 3, first recall that the selection variables are assumed
to account for all differences between the probability distributions in the model
and target, so that P ðÞ¼
ð
y
j
do
ð
x
ÞÞ
Þ . Thus, any P -formula from which S is eliminable
can be directly extrapolated from the model to the target, since in that case
P ðÞ¼
P
ðj
s
P ðÞ
, any P -formula
without a do -operator can be derived from the probability distribution of the target.
In contrast, since no experimental manipulation was performed in the target popu-
lation and selection variables are unmeasured, P probabilities with both an irreduc-
ible do ( u ) and s are unidentifiable. Consider, then, how Theorem 3 applies to the
selection diagram in Fig. 10.2 , when P
P
ðj
s
Þ¼
P
ðÞ
. On the other hand, since P
ðj
s
Þ¼
ð
c
j
do
ð
u
ÞÞ
is the causal effect
to be
extrapolated. This proceeds as follows:
P ð
c
j
do
ð
u
ÞÞ¼
P
ð
c
j
do
ð
u
Þ ;
s
Þ
X
¼
P
ð
c
j
do
ð
u
Þ ;
a
s
Þ
P
ð
a
j
do
ð
u
Þ ;
s
Þ
;
a
X
¼
P
ð
c
j
do
ð
u
Þ ;
a
Þ
P
ð
a
j
do
ð
u
Þ ;
s
Þ
a
X
¼
P
ð
c
j
do
ð
u
Þ ;
a
Þ
P
ð
a
j
s
Þ
a
X
P ð
¼
P
ð
c
j
do
ð
u
Þ ;
a
Þ
a
Þ
a
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