Biology Reference
In-Depth Information
Fig. 10.3 The
U
-manipulated
version of the selection
diagram in Fig.
10.2
I
U
E
C
S
A
Theorem 3.
Let D be the selection diagram characterizing two populations,
and
Π
P
ð
*, and S the set of selection variables in D. The causal effect R
¼
y
j
do
ð
x
ÞÞ
Π
can be extrapolated from
* if and only if the expression P
(
y
|
do
(
x
)
,S
)
is
reducible, using the rules of do-calculus, to an expression in which no do-operator
is conjoined with S.
(Pearl and Bareinboim
2011
, p. 32)
to
Π
Π
As noted above, the causal effect of
X
upon
Y
, represented by the formula
P
,
is the probability distribution of
Y
conditional on an intervention on
X
.Aninterven-
tion or manipulation on
X
is an exogenous cause that targets
X
alone and eliminates
all other causes of
X
. To illustrate, consider the
U
-manipulated version of the
selection diagram from Fig.
10.2
(i.e., the version of that diagram resulting from an
intervention on the variable
U
). As shown in Fig.
10.3
, this modified selection
diagram eliminates the confounding arcs and adds a new variable labeled
I
,
representing the intervention, with an arrow pointing directly into
U
. The do-calculus
consists of three basic rules, derived from the Markov condition, for manipulating
probabilities that contain
do
-operators, such as
do
(
x
)(Pearl
2000
, pp. 85-86).
To understand Theorem 3, first recall that the selection variables are assumed
to account for all differences between the probability distributions in the model
and target, so that
P
ðÞ¼
ð
y
j
do
ð
x
ÞÞ
Þ
. Thus, any
P
-formula from which
S
is eliminable
can be directly extrapolated from the model to the target, since in that case
P
ðÞ¼
P
ðj
s
P
ðÞ
, any
P
-formula
without a
do
-operator can be derived from the probability distribution of the target.
In contrast, since no experimental manipulation was performed in the target popu-
lation and selection variables are unmeasured,
P
probabilities with both an irreduc-
ible
do
(
u
) and
s
are unidentifiable. Consider, then, how Theorem 3 applies to the
selection diagram in Fig.
10.2
, when
P
P
ðj
s
Þ¼
P
ðÞ
. On the other hand, since
P
ðj
s
Þ¼
ð
c
j
do
ð
u
ÞÞ
is the causal effect
to be
extrapolated. This proceeds as follows:
P
ð
c
j
do
ð
u
ÞÞ¼
P
ð
c
j
do
ð
u
Þ
;
s
Þ
X
¼
P
ð
c
j
do
ð
u
Þ
;
a
s
Þ
P
ð
a
j
do
ð
u
Þ
;
s
Þ
;
a
X
¼
P
ð
c
j
do
ð
u
Þ
;
a
Þ
P
ð
a
j
do
ð
u
Þ
;
s
Þ
a
X
¼
P
ð
c
j
do
ð
u
Þ
;
a
Þ
P
ð
a
j
s
Þ
a
X
P
ð
¼
P
ð
c
j
do
ð
u
Þ
;
a
Þ
a
Þ
a
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