Biomedical Engineering Reference
In-Depth Information
ligaments such as the ACL should be performed in cranial cruciate
ligament replacement (CrCL) models developed in dogs, sheep
[VIA 13a], goats or mini-pigs. Goats and sheep with increased
extension of the knee and low tibial slopes should be preferred over
dogs and pigs, to mimic as far as possible the biomechanical clinical
setting in which the TEC will be used.
Defect
Size
Width
Study
length
(weeks)
Animal
Species
Reference
Joint
deepness
(mm)
×
Rabbits
[ORT 13]
stifle
3
×
5
3
Rabbits
[KIM 10]
stifle
3-6
3
×
2,5
Rabbits
[LAF 13]
stifle
3
1,4
×
2
Rabbits
[RAS 13]
tibia
3
3-6-12
13.5
×
8.4
×
Dogs
[WAL 13]
stifle
12-24
8.4
Mini-pigs
[MUE 09]
stifle
8
6
×
1
Pigs
[LI 09]
stifle
7
26
Sheeps
[KON 10]
stifle
7
×
9
26
Sheeps
[AKE 01]
stifle
5.4
×
6
26-52-78
Goats
[RAU 13]
stifle
3.5
×
3
26
Goats
[CHA 12]
stifle
26
26-52
Non-human
primate
[BUC 03]
stifle
8
3.2
×
4
Table 8.4.
Commonly used animal models for preclinical evaluation
of cartilage engineered construct
Tendon engineering
Currently used models in the field of ligament or tendon
engineering, have been described in goats, sheep and mini-pigs.
Specific models have been developed according to the future fields of
application of the TEC: repair procedures of lesions created in the
patellar, Achilles rotator cuff tendon [HAS 14].
