Chemistry Reference
In-Depth Information
TABLE 5.5. Second-Order Rate Constants of Peroxynitrite Reactions with Protein
and Nonprotein Metal Centers
pH
a
Metal Center
t
(°C)
k
(/M/s)
Reference
Mn(III)-tm-2-pyp
b
7.4
37
1.85 × 10
7
[226]
Mn(III)-tm-3-pyp
b
7.4
37
3.82 × 10
6
[226]
Mn(III)-tm-4-pyp
b
7.4
37
4.33 × 10
6
[226]
Fe(III)-tm-4-pyp
b
7.4
37
2.2 × 10
6
[227]
Fe(III)-tmps
c
6.45 × 10
5
7.4
37
[227]
Fe(III)EdTA
d
7.5
37
5.7 × 10
3
[199]
Fe(III)-myeloperoxidase
7.0
25
6.8 × 10
6
[228]
Fe(II)-myeloperoxidase
7.0
25
1.3 × 10
6
[228]
Compound I
7.0
25
7.6 × 10
6
[228]
Ni(II)-cyclam
e
NR
27
3.25 × 10
4
[201]
Mn(III)-tbap
f
7.2
37
6.8 × 10
4
[229]
Zn(II)-tbap
f
4.9 × 10
5
7.2
37
[229]
Myeloperoxidase (heme)
7.2
12
6.2 × 10
6
[230, 242]
Lactoperoxidase (heme)
7.4
12
3.3 × 10
5
[230, 242]
Horseradish peroxidase (heme)
Ind
g
25
3.2 × 10
6
[230, 242]
Alcohol dehydrogenase (zinc
sulfur cluster)
7.4
23
2.6 × 10
5
[231]
Aconitase (iron sulfur cluster)
7.6
25
1.4 × 10
5
[232]
Cytochrome c
2+
(heme)
7.4
25
1.3 × 10
4
[233]
7.4
37
2.5 × 10
4
[233]
Metmyoglobin (metMb)
7.4
20
1.0-1.4 × 10
4
[234, 243]
5.8 × 10
6
H64A metMb
7.5
20
[235]
H64d metMb
7.5
20
4.8 × 10
6
[235]
H64L metMb
7.5
20
5.7 × 10
4
[235]
F43W/H64L metMb
7.5
20
5.2 × 10
4
[235]
H64y/H93g metMb
7.5
20
0.9 × 10
4
[235]
sw WT-metMb
7.5
20
1.6 × 10
4
[235]
hh metMb
7.5
20
1.2 × 10
4
[236]
1.04 × 10
4
Oxyhemoglobin (monomer)
7.4
25
[237]
NR
20
2-3 × 10
4
[238]
Mn superoxide dismutase
(monomer)
7.4
37
2.5 × 10
4
[229]
Mn(II) superoxide dismutase
8.0
13
3.0 × 10
2
[239]
Mn(III) superoxide dismutase
8.0
13
1.0 × 10
2
[239]
Cu,Zn superoxide dismutase
(monomer) 7.5
37
9.4 × 10
3
[240]
Tyrosine hydroxylase
7.4
25
3.8 × 10
3
[241]
a
pH: This column shows the pH at which the rate constant was determined.
b
tmpyp: 5,10,15,20,-tetrakis(N-metil-40-pyridyl)porphyrin.
c
tmps: 5,10,15,20,-tetrakis(2,4,6-trimetil-3,5-sulfonatofenil)porphyrin.
d
EdTA: ethylenediaminetetraacetic acid.
e
cyclam: 1,4,8,11-tetraazacyclotetradecane.
f
tbap: tetrakis-(4-benzoic acid) porphyrin.
g
ind: pH-independent value.
NR, not reported.
Search WWH ::
Custom Search