A History of Iron Metabolism in the Mycobacteria - Iron Acquisition by the Genus Mycobacterium - page 33

Fig. 2.10 An early model proposed to explain iron uptake and transport in the mycobacteria [ 98 ]
Fig. 2.11 Possible mechanisms for iron uptake in mycobacteria as further elucidated during the
1980s and 1990s [ 113 ]. FeRex an extracellular ferric reductase, FeR ferric-mycobactin reductase,
My mycobactin, Rep receptor protein for exochelin, FxuA , FxuB etc. ferric-exochelin uptake pro-
teins, ExiT exochelin transport protein, FxbA , FxbB , etc. ferric-exochelin biosynthesis proteins,
Bfr bacterioferritin, ? unknown mechanisms but the uptake of ferric-carboxymycobactin is now
known to involve an ABC transporter
ferric ammonium citrate. Iron storage within the cytoplasm of the cell is by bac-
terioferritin [ 109 - 111 ] but only when the iron is in excess of immediate metabolic
requirements. Bacterioferritin receives the iron being released by ferrimycobactin