Biomedical Engineering Reference
In-Depth Information
to the presence of chiral nanoparticles, one type of the optically
active enantiomers radiates e
ciently and goes to ground state
quickly, while the remaining excited enantiomers can be ionized
by a resonant field, and then removed from the chamber. Other
methods of removal of excited molecules or their decay products
are also possible. As a result, the desired pure enantiomer will be
accumulated in the chamber. Our approach to pure optical spatial
separationofenantiomershassomeadvantagesincomparisonwith
other proposal [51], because we have no need to use very low
temperatures.
4.6 Conclusion
Thus, in this Chapter, the radiation of optically active molecules
is considered for different chiral meta-environment such as a
half-space, single nanoparticle, and a nanoantenna made of two
metaparticles. We have shown that all these geometries allow one
to control radiation of different enantiomers by his will. The degree
ofthiscontrolisincreasedfromachiralhalf-spacetoananoantenna,
where the enhancement of local fields and chiral discrimination
is maximal. It is very important to note that such a control is
impossiblewithoutmakinguseofmodern
μ
negative(MNG)and/or
double-negative(DNG) metamaterials.
The possibility to arrange a system in which “right” and “left”
molecules have different decay rates pave the way to different
applications starting from the detection of a single “right” DNA
molecule among millions of usual “left” DNA molecules to develop
devicesforseparationofenantiomersduringdrugmassproduction.
Acknowledgments
The authors thank the Russian Foundation for Basic Research
(VK, grants numbers 11-02-91065, 11-02-92002, 11-02-01272,
and 12-02-90014) and the Belarusian Republican Foundation for
Fundamental Research (DG, grant number F12R-006) for partial
financial support of this work.
