Biology Reference
In-Depth Information
AMIDE
O
O
C
C
H
C
PROTEIN
H
2
NH
MYRISTIC ACID
N-terminal
GLYCINE
MYRISTOYLATED PROTEIN
FIGURE 6.10
Myristoylated protein. Protein is N-myristoylated through an amide to its N-terminal glycine.
protein
thioester
O
NH
C
O
H
2
CYSTEINE
C
CH
C
S
NH
protein
PALMITIC ACID
PALMITOYLATED PROTEIN
FIGURE 6.11
Palmitoylated protein. Protein is S-palmitoylated through a thioester to a cysteine near the
protein's N-terminal.
FIGURE 6.12
Prenylated proteins.
Proteins attached through a thioether to
either farnesyl (15-carbons, 3-isoprene
units) or geranylgeranyl (20-carbons,
4-isoprene units) at a C-terminal cysteine
on the protein.
O
O
thioether
C-terminal
C
CYSTEINE
H
S
C
H
2
C
H
NH
FARNESYL
protein
O
O
thioether
C-terminal
C
CYSTEINE
H
S
C
H
2
C
H
NH
GERANYLGERANYL
protein
PRENYLATED PROTEIN
