Biology Reference
In-Depth Information
CHAPTER
11
Long-Ra
nge Membrane P
roperties
OUTLINE
A. Membrane Bilayer Lipid Packing
215
Clathrin-Coated Pits
226
Lipid Packing Free Volume
215
Caveolae
226
Lipid Monolayers (Langmuir Film
Balance)
2. Lipid Microdomains
227
217
D. Homeoviscous Adaptation
232
Area/Molecule
219
Acyl Chain Length
232
Lipid 'Condensation'
220
Acyl Chain Double Bonds
233
Surface Elasticity Moduli, C
s
1
221
Phospholipid Head Groups
233
Lipid 'Squeeze Out'
221
Sterols
233
B. Membrane Protein Distribution
222
Isoprene Lipids
233
Freeze Fracture Electron
Microscopy
Anti-freeze Proteins
233
222
Divalent Metals
233
Don Juan Pond
234
C. Imaging of Membrane Domains
223
1. Macrodomains
223
Summary
235
Membrane Macrodomains
224
References
235
Gap Junctions
224
Chapter 11 will discuss a few large-scale membrane properties including lipid bilayer
packing, membrane protein distribution, membrane lipidmicro-domains, and finally a process
that keeps all of the various membrane properties in synch, homeoviscous adaptation.
A. MEMBRANE BILAYER LIPID PACKING
Lipid Packing Free Volume
It has been well-documented that the large-scale state of the lipid bilayer componemt of
membranes has a profound impact on the activity of resident membrane proteins
[1,2]
.
