Biology Reference
In-Depth Information
CHAPTER
10
Lipid
Membrane Prop
erties
OUTLINE
A. Complex Lipid Interactions
176
3. Non-Anionic Co-Factor Lipids
200
Lipid Affinities
176
Rhodopsin
200
A
DSC Study
178
D-
-Hydroxybutyrate
Dehydrogenase
b
An X-Ray Diffraction Study
179
202
Lipid Raft Detergent Extractions
181
Cytochrome c Oxidase
202
4. Hydrophobic Match
203
B. Non-Lamellar Phases
182
The Hydrophobic Match Length:
A DSC Study
Inverted Hexagonal Phase (H
II
)
185
203
Cubic Phase
186
Biological Function of the
Hydrophobic Match
31
-P-NMR
187
205
C. Lipid Phase Diagrams 190
Single-Component Lipid Phase Diagrams 190
Two-Component Lipid Phase Diagrams 191
A Three-Component Lipid Phase Diagram192
E. Lipid Interdigitation
206
Interdigitated-Lipid Shape
206
Interdigitated Structure is Inherent
in Symmetrical Chain Phospholipids
208
D. Lipid
Protein Interactions
194
Methods to Detect Interdigitation
209
e
1. Annular Lipids
194
Interdigitation Caused by
Perturbations
2. Co-Factor (Non-Annular) Lipids
197
209
Ca
2þ
ATPase
198
Biological Relevance
210
Protein Kinase C
199
Summary
210
Na
þ
/K
þ
ATPase
199
Potassium Channel KcsA
199
References
211
The previous chapter (Chapter 9) investigated some of the major principles of the Fluid
Mosaic model. While these principles form the core of understanding basic membrane struc-
ture, there are many other, more poorly understood membrane properties and concepts that
must be considered. Membranes are just very complex. Several of these properties will be
discussed in Chapters 10 and 11.
