Biology Reference
In-Depth Information
membrane-soluble agents. It is predicted that anything that will increase membrane
viscosity will decrease 'fluidity'. Examples include decreasing temperature, increasing
pressure, increasing cholesterol content, and altering environmental pH and ionic
strength. In addition, the nature of the phospholipid head groups and acyl chains, as
well as favorable and unfavorable lipid
protein interactions, will also
affect 'fluidity'. These concepts will be discussed in Chapter 10 under 'homeoviscous
adaptation'.
lipid and lipid
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SUMMARY
Every aspect of membrane structural studies involves parameters that are very small
(micron to angstrom) and very fast (microseconds to picoseconds) requiring an array of
esoteric biophysical methodologies. Membrane parameters discussed in this chapter include:
membrane thickness, bilayer stability, membrane protein, carbohydrate and lipid asymme-
try, lipid trans-membrane movement (flip-flop), membrane lateral diffusion, membrane-
cytoskeleton interaction, lipid melting behavior, and membrane 'fluidity'. These basic
membrane properties were discovered by countless investigators over ~7 decades and
formed the basis of the Singer-Nicholson Fluid Mosaic model of membrane structure that
is currently in vogue.
Chapter 10 will continue the discussion of membrane physical properties including:
lipid affinities, lipid phases, lipid
protein interactions (hydrophobic match), and lipid
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interdigitation.
References
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