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Figure 9.14
Stepwise assembly of salen ligand and the salen metal base pair inside the DNA
double helix.
interfering T-Hg(II)-T base pair as shown in Figure 9.15b. Likewise, it was demonstrated
that the hydroxypyridone-Cu(II) base pair could be combined with the pyridine-Hg(II)
base pair in order to create mixed metal arrays (not shown) [49]. Since the sequential
nature of the solid-phase oligonucleotide synthesis process unambiguously determines
the order of the incorporated ligands and titration and mass spectrometry experiments
showed the binding of the anticipated number and type of metal ions to these ligands, the
systems can be regarded as programmed assemblies of linear chains of two kinds of metal
ions that might find future application in DNA-based molecular electronics. In a related
work, Ono et al. were recently able to incorporate T-Hg(II)-T and C-Ag(I)-C base pairs
into the same double strand [52].
Figure 9.15 (a) Stacking of ten consecutive salen metal base pairs and (b) assembly of mixed
metal arrays from strands containing a programmed sequence of salen ligands and T-T mis-
matches using Cu(II) and Hg(II) ions.
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