Chemistry Reference
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Figure 8.21 Two peptide strands 32 and 33 with non-natural binding sites (e.g., X) in
i
and
i
รพ
4
position of a peptide which upon metal coordination induce a-helical structures and
unnatural amino acids A and B appropriate as building blocks to be incorporated into peptides.
The metallopeptide
34
represents an achiral peptide (Figure 8.22) in which a short 3
10
-
helix is stabilized by the coordination of platinum(II) or palladium(II). Metallopeptide
34
shows some decelerated chirality interconversion upon coordination of the metals to the
side chain pyridines [59].
Figure 8.22 An optically inactive 3
10
-helical peptide, stabilized by palladium(II) or platinum
(II) coordination.
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