Biology Reference
In-Depth Information
Table 2.1 Pathogenetic Association of miRNAs in Human Disease
Phenotypic Feature
MiRNA Identifier
Reference
Cell lineage
miRNA-125/lin-4, Let-7
CNS development,
neuron migration
miRNA-103, 107
Mancini et al. (2011)
Bone remodelling
miRNA-29 family
Kapinas and Delany (2011)
Cellular senescence
miRNAs 23a, 26a, 30a
Lee et al. (2011)
Cardiovascular
physiology, disease
miRNA-155,
miRNA-21, miRNA-126
Urbich et al. (2008)
Tumours/Cell Lines
Lymphoma (cells nasal)
EBV miRNAs
Ramakrishnan et al. (2011)
MCF-7 (breast cancer)
miRNAs 21, 182,
let7-5a overexpressed
miRNAs-145, -155
reduced expression
Roa et al. (2010)
Du-145 (prostate cancer),
U118 (glioblastoma)
Synovial sarcomas
and cell
Let-7e, miRNAs
99b, 125a-3p
Hisaoka et al. (2011)
Tumour Promotion
EMT activation
miRNA-335
Zhang et al. (2012c)
Apoptosis suppression
miRNAs-17-92
miRNA-21
Finoux and Chartrand (2008)
Carletti et al. (2010), Chan
et al. (2005), Zhou et al.
(2010b)
Promotion of
cell motility
DNA damage/NF-κB →
miRNA-21↑
Niu et al. (2012)
Breast cancer
miRNA-21 ↑
Si et al. (2007)
Synovial sarcomas
Let-7e, miRNAs 99b,
125a-3p, among the
21 found to be regulated.
Hisaoka et al. (2011)
Synovial sarcoma,
rhabdomyosarcoma
and colon cancer
miRNA-183
Sarver et al. (2010)
Gastric cancer/cells
miRNA-223 among
16 miRNAs upregulated.
miRNA-223 increased in
vitro invasion
Li et al. (2011c)
Gastric primary and
metastatic tumours
miRNA-199a
Song et al. (2010a)
oesophageal
adenocarcinoma,
high-grade dysplasia
miRNA-196a
Maru et al. (2009)
Inhibition of platelet-derived
growth factor (PDGF)-
induced downregulation
of p27Kip1
miRNA-221
Davis et al. (2009)
Downregulation of PDGF
miRNA-219
 
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