Biology Reference
In-Depth Information
Table 3.1
miRNAs in Drug Resistance and Radiosensitivity
miRNA
Drug Resistance, Radiosensitivity
Reference
Let-7
Lin28-let7a
van Jaarsveld et al.
(2010)
Oh et al. (2010)
miRNA-200
miRNA-214
miRNA-130a
miRNA-27, miRNA-451
P-glycoprotein ↑
Zhu et al. (2008a)
miRNA-326↓
MCP-1↑
Liang et al. (2010b)
miRNA-451↑
miRNA-224↓
Cisplatin sensitivity↑
Methotrexate cisplatin sensitivity↓
Bian et al. (2011)
Mencia et al. (2011)
miRNA-106a↑
5-FU sensitivity↑
Hummel et al. (2011)
miRNA-148a↑
Cisplatin, 5-FU sensitivity↑
Hummel et al. (2011)
miRNA-195↑
5-FU sensitivity↑
Yang et al. (2012)
MiRNA-141
miRNA-27a
Cisplatin
miRNAs↑
P-glycoprotein↑
Paclitaxel P-glycoprotein
Imanaka et al. (2011)
Li et al. (2010g)
Doxorubicin sensitivity↑
Zhang et al. (2010b)
miRNA-199a-3p
miRNA-326
Doxorubicin, VP-16
sensitivity↑
Fornari et al. (2010)
Liang et al. (2010b)
miRNA-331-5p; miRNA-27a
P-glycoprotein↓ in doxorubicin-
resistant cells; sensitivity↑
Feng et al. (2011a)
miRNA-122↑
Adriamycin vincristine
sensitivity↑MDR-1
Xu et al. (2011b)
MiRNA-24
Topotecan, Irinotecan sensitivity↓
Topotecan IFN-α/5-FU
Trastuzumab (Herceptin)
Gmeiner et al. (2010)
miRNA-21
Doxorubicin
Misawa et al. (2010)
Tomimaru et al. (2010)
Gong et al. (2011)
miRNA-21
miRNA-21↓ inhibition
Taxol sensitivity↑ with inhibitor
Ara-C (arabinosylcytosine)
sensitivity↑
Tao et al. (2011)
Ren et al. (2010b)
miRNA-21↓ (anti-sense
oligonucleotide)
Docetaxel
Li et al. (2010e)
miRNA-21↓ (inhibited)
miRNA-100, miRNA-130a,
miRNA-197↓ miRNA-101,
miRNA-181b, miRNA-181d,
miRNA-195↑
Docetaxel sensitivity↑
Dai et al. (2011b)
miRNA-143↑
Paclitaxel
Xu et al. (2011a,b)
miRNA-125b
miRNA-135a
Paclitaxel
Zhou et al. (2010a)
Holleman et al. (2011)
Note
: ↓indicates downregulation of expression or reduction of drug sensitivity; ↑ indicates upregulation of expression or
increased resistance; where no symbols are shown and a direct correlation between expression and drug resistance is implied.
Search WWH ::
Custom Search