Biology Reference
In-Depth Information
Maspin increases adhesive interaction between the endoderm and to ECM com-
ponent laminin matrix. Maspin−/− endoderm proliferated more slowly than
Maspin+/+ cells on laminin substratum (Gao et al., 2004). The engagement of inte-
grin receptors by laminin regulates cell adhesion and migration. Consistent with this
is the inverse relationship noticed between Maspin expression and expression of uPA
(urokinase-type plasminogen activator) and uPAR (uPA receptor) in oral squamous
cell carcinomas (Yoshizawa et al., 2011). Maspin might be localised and its adhe-
sion function promoted by the uPA/uPAR system. Maspin, uPA/uPAR and β1 integ-
rin might be functioning as a complex (Endsley et al., 2011). This could be a means
by which Maspin regulates cell adhesion and inhibits cell motility. Maspin co-pre-
cipitates with α3β1 and α5β1 integrins. Binding of Maspin to α5β1 inhibited the acti-
vation of the integrin. Maspin inhibited migration of CHO (Chinese hamster ovary)
cells overexpressing α5β1 but not of those that lacked it indicating that it mediated
the inhibition (Bass et al., 2009). The enhanced adhesive effects of activation of the
β1 integrin ECM component are transduced down the vinculin/actin cytoskeletal
system (Qin and Zhang, 2010).
Search WWH ::
Custom Search