Biomedical Engineering Reference
In-Depth Information
found. These thickness of fibrous capsule indicated well within the critical tissue tolerance
range. It was given by the some reporters that the threshold capsule thickness should not
exceed 200-250 m for an implanted biomaterial (Jeyanthi and Rao, 1990). Our results
clearly indicated that the capsule thickness of the excised tissue were well within these
stipulated threshold limits. On the basis of the findings we can conclude that the biological
response against the tested hydrogels was very similar to the biocompatibility of very low
swollen of poly(2-hydroxyethyl methacrylate) hydrogel, which considered as a biologically
inert polymer (Smetana et al., 1990). However, it is important that the swelling of
acrylamide based hydrogels are very high than the swelling of poly(2-hydroxyethyl
methacrylate) hydrogels for the biomedical uses.
Graphic 2
.
The curves of thickness of fibrous capsule—implantation time.
4. Bioactive ceramic biomaterials
Bioactive refers to a material, which upon being placed within the human body interacts
with the surrounding bone and in some cases, even soft tissue. This occurs through a time -
dependent kinetic modification of the surface, triggered by their implantation within the
living bone. An ion - exchange reaction between the bioactive implant and surrounding
body fluids - results in the formation of a biologically active carbonate apatite (CHAp) layer
on the implant that is chemically and crystallographically equivalent to the mineral phase in
bone. Prime examples of these materials are synthetic hydroxyapatite,
glass ceramic and
bioglass.
Calcium phosphate ceramics and xenografts have been used in different fields of medicine
and dentistry. We demonstrated the effects of calcium phosphate ceramics (Ceraform) and
xenograft (Unilab Surgibone) in the field of experimentally created critical size parietal and
mandibular bone defects in rats (Develioglu et al., 2006, 2007, 2009, 2010).
Many researches are currently conducted to find out the ideal material to support bone
repair or regeneration. The limitations of autogenous grafts and allogeneic bankbone have
led to a search for synthetic alloplast alternatives. Calcium phosphate ceramics have been
