Biomedical Engineering Reference
In-Depth Information
Galectin-1
Galectin-3
Galectin-8 N-CRD
Galectin-8 C-CRD
Complex
N
-glycans
Increasing affinity
with increasing
number of antennas
N
-glycans,
preferred poly-
LacNAc
N
-glycans and
glycosphingolipids
(e.g. GM3 and
GD1a)
N
-glycans,
preferred poly-
LacNAc
Cer
Non-reducing
terminal LacNAc
type I or II (grey in
upper scheme)
Non-reducing
terminal and
internal LacNAc,
high affinity for
repetitive LacNAc-
units (grey in upper
scheme)
Preference for
lactose (but also
binding to LacNAc-
units)
LacNAc type I or II
high affinity for
repetitive LacNAc-
units (grey in upper
scheme)
β4
β3/4
β3/4
β4
3-O-sulfation
3 O-sulfation
3 O-sulfation and
α3-sialylation
SO
4
SO
4
β3/4
β4
SO
4
β4
α3 β4
Blood group A and
B antigens
Blood group A and
B antigens
α2
α
2
α3 β4
α3 β4
α2
α
α3 β4
α3 β4
Table 1. Preferred ligands of the single carbohydrate recognition domains of galectin-1, -3
and -8 following Rapoport et al. 2002. Symbols according to the consortium of functional
glycomics (Brewer, 2004; Carlsson et al., 2007; Dell, 2002; Hirabayashi et al., 2002; Ideo et al.,
2003; Ideo et al., 2011; Leppänen et al., 2005; Patnaik et al., 2006; Rabinovich & Toscano,
2009; Rapoport et al., 2008; Salomonsson et al., 2010; Stowell et al., 2004; Stowell et al., 2008a;
Yamamoto et al., 2008)
