Research on Mg-Zn-Ca Alloy as Degradable Biomaterial - Biomaterials: Physics and Chemistry - page 203

4. Conclusion
In this paper, we developed ternary Mg-Zn-Ca alloys as biodegradable materials. The
following conclusions can be drawn.
The mechanical properties of the as-cast Mg-Zn-Ca alloys can be tailored by the Zn and Ca
content. The tensile strength can be increased form 105MPa to 225Mpa, and the elongation
can be increased from 4.2% to17 %.
The in-vitro degradation of Mg- Zn- Ca alloys revealed that Zn and Ca not only elevated the
corrosion potential of the magnesium alloys, but also influence their corrosion current. A
protective layer of Mg(OH) 2 and other Mg/Ca phosphates was formed on the surface of
Mg- Zn- Ca alloys when immersed in SBF solution ,which declined the degradation rate.
In vitro cytotoxicity assessments indicated that Mg-4.0 Zn-0.2Ca alloy did not induce
toxicity in L-929 cells and are suitable for biomedical applications.
Implanted in rabbits, the alloy did not induce inflammation reactions or affect the new bone
formation. We could draw a conclusion that the Mg-4.0Zn-0.2Ca alloy had good
biocompatibility.
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